• br Inclusion exclusion criteria br Quality assessment All

  2022-04-11

  

  Inclusion/exclusion criteria Quality assessment All studies included in the qualitative synthesis were evaluated using the Quality Assessment Tool for Quantitative Studies (QATQS), which allows to determine their methodological quality. QATQS assesses 8 sections: selection bias, study design,

• A oligomers increased ubiquitination of GLT

  2022-04-11

  

  Aβ1-42 oligomers increased ubiquitination of GLT-1 in astrocytes. Previous studies found that astrocytic GLT-1 is internalized from the cell surface by ubiquitination of lysines located in the cytoplasmic C-terminus of the transporter (Gonzalez-Gonzalez et al., 2008, Martinez-Villarreal et al., 2012

• Genomic studies have afforded new

  2022-04-09

  

  Genomic studies have afforded new insight into the influence of galactoside structure on GR binding. An important clue came from genome-wide mapping of chromatin structure using DNase I hypersensitive site sequencing (DNase-seq), and comparing the locations of open chromatin to GBSs [10]. DNase-seq

• In the upper part of

  2022-04-09

  

  In the upper part of the intestine a small amount of conjugated BAs are reabsorbed via passive diffusion, whereas the part of BAs that escape enterohepatic circulation passes into the colon where they undergo bacterial conversions such as deconjugation, dehydroxylation or dehydrogenation, into secon

• br Melanoma cell lines There

  2022-04-09

  

  Melanoma cell lines There is suggestive epidemiological evidence that omega-3 PUFA can be preventative against melanoma, although the mechanisms of this relationship has not been extensively investigated [65], [66]. A 2014 study demonstrated that DHA inhibited cell proliferation in vitro in A2058

• The first phase of insulin

  2022-04-09

  

  The first phase of insulin secretion is due to calcium signaling because of glucose sensing, increased cytoplasmic ATP levels, cellular depolarization, calcium influx and activation of calcium sensing molecules that eventually causes the fusion of the insulin granules to plasma membrane (exocytosis)

• The stable association of Hat complexes with

  2022-04-09

  

  The stable association of Hat1 complexes with histones H3 and H4 raises a number of interesting issues. The first is the question of how Hat1 remains stably associated with histones H3 and H4. While the simple answer is that Hat1 remains bound to histones because of its association with histone chap

• Tylophora atrofolliculata is a centuries used folk medicine

  2022-04-09

  

  Tylophora atrofolliculata is a centuries-used folk medicine for the treatment of rheumatism in China (Jiangsu New Medical College, 1977). One group of its bioactive components is phenanthroindolizidine alkaloids, which have been demonstrated as lead compounds of anti-tumor agents in our previous stu

• Our investigation also showed NAC increased the level of DAF

  2022-04-09

  

  Our investigation also showed NAC increased the level of DAF and might protect HUVECs from complement activation. NAC, an antioxidant/mucous modifier, has displayed benefits in chronic obstructive pulmonary disease. Martinez de Lizarrondo et al [38] provided evidence that the molecular target underl

• Mammals have three known Gli

  2022-04-09

  

  Mammals have three known Gli proteins: Gli-1, -2 and -3. Gli-1 does not undergo proteosomal degradation and hence, remains untruncated and always acts as a transcription promoter. Gli-1 is an important target gene for Gli-2. Full-length Gli-2 accumulates when Smo is activated because activated Smo p

• br Acknowledgments br Introduction Histone

  2022-04-08

  

  Acknowledgments Introduction Histone deacetylases (HDACs) related to tumor suppressor genes have become promising targets for the treatment of cancer [1,2]. Under the normal physiological conditions, Histone acetyltransferases (HATs) and histone deacetylases (HDACs) together regulate the acety

• The prevalence of hepatitis C virus HCV infection in

  2022-04-08

  

  The prevalence of hepatitis C virus (HCV) infection in p.C282Y homozygotes in North America is unknown. We determined the prevalence of anti-HCV antibody and HFE genotype and serum ferritin (SF) associations in non-Hispanic white participants in the Hemochromatosis and Iron Overload Screening (HEIRS

• In mammals meiotic maturation is the process that

  2022-04-08

  

  In mammals, meiotic maturation is the process that couples completion of MI with the acquisition of developmental competence to support fertilization (Figure 1). In females there are several hallmark maturation events that are linked to the cell cycle. First, meiosis is not continuous, it is initiat

• br Role of dynamin in

  2022-04-08

  

  Role of dynamin in NPRA endocytosis In recent studies using 125I-ANP binding assay and confocal microscopy, we have examined the role of dynamin in the internalization and trafficking of NPRA in a stably transfected HEK-293 α-Cyperone [69]. Our findings indicated that ANP treatment of high-densit

• In conclusion LA is able

  2022-04-08

  

  In conclusion, LA is able to enhance osteoblast differentiation that mediated by PTH in a MCT-1 independent but GPR81 signaling dependent manner. This increase requires p38 activation and an Akt activation that depended on Gβγ-protein-PLC-PKC signaling. However, the ability of LA to increase PTH–med

15620 records 450/1042 page Previous Next First page 上5页 446447448449450 下5页 Last page