• To study the role of DNA

  2021-05-25

  

  To study the role of DNA–PK in the response to replication arrest, we used the DNA replication inhibitor aphidicolin (APH). APH, a mycotoxin isolated from Cephalosporium aphidicola, inhibits DNA replication by interacting with the replicating DNA polymerase α (pol α). APH specifically inhibits the a

• This project was funded by the Deutsche Forschungsgemeinscha

  2021-05-25

  

  This project was funded by the Deutsche Forschungsgemeinschaft within FOR 2251 (project grants EB 285/2-1 and WI 3272/3-1) and in part by additional contributions from the Bundesministerium für Bildung und Forschung (D.I.S award Nos. BIOSCAT [05K12YE1]) and the Horizon 2020 programme of the European

• br Enzymes repairing alkylated DNA

  2021-05-25

  

  Enzymes repairing alkylated DNA Induction of the Ada regulon Methylated Ada is a strong activator for ada and alkA promoters. Although much weaker than the methylated form, unmethylated Ada acts alone as an activator for ada and alkA promoters. In contrast, the unmethylated protein present in

• For example nM MTX markedly stimulates the differentiation

  2021-05-25

  

  For example, 200nM MTX markedly stimulates the differentiation of the monocytic U937 ctep [39], but only 10nM MTX is sufficient for the inhibition of clonogenicity in the ALL and APL cell lines [22]. Furthermore, an even lower concentration of MTX (2nM) selectively induces the expression of p27 and

• br Electron transfer pathway Intramolecular or

  2021-05-25

  

  Electron transfer pathway Intramolecular (or inter-domain) electron transfer (IET) in CDH has been studied in much depth [], and similar IET occurs in CcPDH, from the PQQ cofactor in the AA12 domain to the heme b in the AA8 domain. When two kinds of electron acceptors are used for measuring enzym

• br Role of CRF receptors in the

  2021-05-25

  

  Role of CRF1 receptors in the BNST in stress-induced relapse to cocaine seeking The seminal work of Stewart and co-workers [19] showed that rats that have extinguished their auto-administration of different drugs of abuse relapse to drug-seeking behaviour when exposed to footshock, even after a 4

• Compound A and Compound B Fig were found in our

  2021-05-25

  

  Compound A and Compound B (Fig. 4) were found in our in vitro screening assays and have similar CRF1 receptor in vitro profiles (Table 1). When binding was investigated using [125I]-CRF in ex vivo assay, Compound A inhibited binding of [125I]-CRF both in the frontal cortex and the pituitary; however

• A further quandary concerning rediscoveries arises in habita

  2021-05-25

  

  A further quandary concerning rediscoveries arises in habitats modified and frequented by humans, where rediscovered species may occur through accidental or deliberate introductions (Metcalf et al., 2007) rather than having persisted despite adverse conditions. Confusion regarding origin could evoke

• br Conclusions and future perspectives It is now evident tha

  2021-05-25

  

  Conclusions and future perspectives It is now evident that selective ETA or nonselective endothelin receptor antagonism provides therapeutic potentials against a variety of cardiovascular diseases such as hypertension, PAH, and diabetic microvascular dysfunction (Fig. 1). However, PAH is currentl

• In the present study we

  2021-05-25

  

  In the present study, we determined concentration–response relationships for selected synthetic progestogens using in vitro luciferase transactivation assays driven by PR, ARα and ARβ from Murray–Darling rainbowfish () and compared the profiles with those obtained from similar assays based on human

• 9-AC A growing body of data indicates that

  2021-05-24

  

  A growing body of data indicates that endothelial NOS (eNOS) is a rate-limiting enzyme for the synthesis of nitric oxide (NO), its downstream 9-AC molecule. High pathological concentrations of NO produced from inducible NO synthase (iNOS) induce apoptosis, whereas a reduction in the concentrations

• Two GPCR subtypes of interest in the

  2021-05-24

  

  Two GPCR subtypes of interest in the myocardium are the endothelin receptor (ETR) and the α1-adrenergic receptor (α1-AR). Upon ligand binding, these receptors canonically activate the Gαq protein leading to activation of phospholipase C, hydrolysis of phosphatidylinositol 4,5-bisphosphate into diacy

• However in many of the above mentioned

  2021-05-24

  

  However, in many of the above mentioned studies, the NaCl concentrations in the extraction buffers were different from those used here. For instance, in the study that performed cathepsin D extraction from human AD DHEA tissue, the concentration was 150mM [30], while that for the extraction of the c

• br Introduction Epithelial mesenchymal transition

  2021-05-24

  

  Introduction Epithelial-mesenchymal transition (EMT) is a biological process by which epithelial Ciclopirox ethanolamine synthesis lose cell polarity and cell-cell adhesion, and gain mesenchymal features with an increase of migratory and invasive properties [1]. EMT is essential for mesoderm for

• br Introduction The discoidin domain receptors

  2021-05-24

  

  Introduction The discoidin domain receptors (DDRs), DDR1 and DDR2, are unique among the receptor tyrosine kinases (RTKs) in being activated by interaction with the extracellular matrix [1], [2]. Binding to triple-helical collagen is mediated by the receptor extracellular domains that include an N

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