• ABH expression is elevated in prostate carcinomas

  2020-06-20

  

  ABH3 expression is elevated in prostate carcinomas and has been referred to as prostate cancer antigen-1 or PCA-1. ABH3/PCA-1 was proposed as a diagnostic marker for prostate cancers, and suggested as a possible therapeutic target [82]. However, the recent studies of ABH2 and ABH3-null mice indicate

• br Conclusions br Acknowledgements br Introduction Liver can

  2020-06-20

  

  Conclusions Acknowledgements Introduction Liver cancer was the fifth most common cancer and the second leading cause of cancer-related death worldwide [1]. Most of primary liver cancers (70–90%) occurring worldwide are hepatocellular carcinoma (HCC) [2]. Persistent hepatitis B virus (HBV) i

• br Results br Discussion The

  2020-06-20

  

  Results Discussion The most relevant overall finding was that DDR1 is present in myelin and is probably synthesized by oligodendrocytes. This result was supported by three different approaches. First, we detected presence of DDR1 mRNA in myelin by ISH. Second, the pattern of DDR1 immunostainin

• Determination of relative potency EC by dose response assays

  2020-06-19

  

  Determination of relative potency (EC50) by dose response assays in vitro is subject to the same sources of variability as determination of affinity, since the EC50 and Hill slope of the dose response curve are highly dependent on the binding of ligand to a competing receptor that may be present, an

• br Discussion EFTs are sarcomas with almost undifferentiated

  2020-06-19

  

  Discussion EFTs are sarcomas with almost undifferentiated histologic features, consequently their differentiation from other small, blue, round cell tumors may be difficult. Substantial intracellular alvocidib on PAS stain is a useful diagnostic feature. The addition of CD99 and FLI1 immunohisto

• NF B is a family of protein mediators

  2020-06-19

  

  NF-κB is a family of protein mediators that regulate various innate and adaptive immune responses [29,30]. The NF-κB family consists of the following five proteins: c-Rel (Rel); p65 (RelA); RelB; p50(NF-κB1); and p52(NF-κB2). It has been confirmed that NF-κB is activated by TNF family cytokines, suc

• Our previous high throughput screening HTS campaign using

  2020-06-19

  

  Our previous high-throughput screening (HTS) campaign using automated, robust, and sensitive fluorescence based methylergometrine assay [10], [11] led to the identification of several EPAC specific inhibitors (ESIs), and was subsequently followed by extensive hit-to-lead optimizations [20], [21], [

• More and more studies are focused

  2020-06-19

  

  More and more studies are focused on the function role of EPAC1 in cancer proliferation, apoptosis and migration. Recently, it was reported that the EPAC-ERK and AKT signaling pathways promote the B cell antigen receptor (BCR) mediated growth arrest and apoptosis in the B lymphoma cell line WEHI-231

• Enzyme mimics belong to a type of

  2020-06-19

  

  Enzyme mimics belong to a type of rising catalysts which show the similar function with their corresponding natural enzymes [20], [21], [22], [23], [24], [25], [26], [27], although their structures are different from natural enzymes. In the area of prodrug activation, the widely-used enzyme mimics a

• br Material and methods br Results and discussion

  2020-06-19

  

  Material and methods Results and discussion Conclusion The gene encoding the Bos taurus muscle enolase enzyme was successfully isolated and cloned in this study. Optimization of the cloning, gene Resiniferatoxin and purification was performed and protein elution at 95% purity was achieved.

• The aim of this study was to discover and

  2020-06-19

  

  The aim of this study was to discover and characterize a novel thermostable gluten-specific prolyl endopeptidase suitable for use during the mashing step of beer production. Subsequently to express the recombinant enzyme in E.coli and to demonstrate degradation of immunogenic gluten derived peptides

• Emphysema is an important component

  2020-06-19

  

  Emphysema is an important component of COPD, which is responsible for airflow limitation. In the present study, a significant airspace enlargement was observed 21 days after elastase administration. Interestingly, daily administration of olaparib provided greater protection against emphysema as comp

• A recent study reports the expression of glutathione depende

  2020-06-19

  

  A recent study reports the expression of glutathione-dependent enzymes (GGT, GST-isoforms, gamma-glutamylcysteine synthetase, glutathione disulfide reductase and GSH peroxidase) in human primary PT 5\'-Iodoresiniferatoxin in four subsequent passages [33]. In this study, we present phase I and II ac

• A spectrum of therapies came in

  2020-06-19

  

  A spectrum of therapies came in order to counter this misfortune, some of them are discussed below. However, the common problem faced by most of these drugs is their emerging resistance after a span of time. Some of the important drugs reported so far are as: Quinine-based antimalarial drugs (Fig. 1

• br Diseases which have been treated with proteins

  2020-06-19

  

  Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty allopurinol zyloprim derivatives of human insulin bound to HSA have applications in the treatment of diabetes whil

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