• Programmed cell death via apoptosis is associated with a ser

  2020-07-29

  

  Programmed cell death via apoptosis is associated with a series of morphological and biochemical characteristics, including cell shrinkage, the rapid increase of intracellular calcium, nuclear condensation, DNA fragmentation and the formation of apoptotic bodies. Known as a shared feature of most ap

• Seventeen out of a hundred

  2020-07-29

  

  Seventeen, out of a hundred samples, were selected as the most promising and their IC50 of enzymatic inhibition were investigated. Among them, eleven resulted strongly active on both enzymes; five were able to inhibit only tyrosinase and one was strongly active only against elastase. Leaves extract

• amd3100 br Experimental Procedures br Results br Discussion

  2020-07-28

  

  Experimental Procedures Results Discussion Studies of radioactive neurotransmitter release in amd3100 slices have shown to be useful to estimate the effect of dopamine agonists and antagonists on the presynaptic receptors modulating neurotransmitter transmitter release, as well as their mec

• The relationship between glutamine metabolism and de novo py

  2020-07-28

  

  The relationship between glutamine metabolism and de novo pyrimidine biosynthesis is becoming better understood. Low glutamine concentrations have been demonstrated to hinder S-phase progression, presumably by limiting the precursor metabolite for nucleotide production (DeBerardinis & Cheng, 2010; G

• The clinical consequences of variations in metabolism depend

  2020-07-28

  

  The clinical consequences of variations in metabolism depend on whether the drug taken is pharmacologically active or is a prodrug that needs to be converted to an active metabolite. If the antipsychotic is pharmacologically active, the PM phenotype will result in increased plasma concentration. Man

• br Acknowledgments We would like

  2020-07-28

  

  Acknowledgments We would like to thank the Bloomington Stock Center and the Vienna Drosophila RNAi Center for stocks used in this study. RMG was supported in part by a Professors grant to R. Losick from the HHMI and this work was supported by NSF grant 074578 to A.A.N. Introduction The catabo

• br Experimental section br Results br Discussion In

  2020-07-28

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised d-glucose sale did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patien

• Introduction Progesterone also known as P is

  2020-07-28

  

  Introduction Progesterone, also known as P4, is a steroid hormone acting as a key component in the complex regulation of female reproductive function. P4 plays major physiological roles in the uterus and ovary by releasing mature oocytes helping in 234 2 and maintenance of pregnancy, as well as in

• br Materials and method br Results br Discussion We

  2020-07-28

  

  Materials and method Results Discussion We hypothesized that higher levels of dopamine would be beneficial to cognition in postmenopausal women. We operationalized increased levels of dopamine with being Met/Met homozygous for the COMT gene. Women who are homozygous for Met have less transc

• Protein tyrosine kinases PTKs of Src family are

  2020-07-28

  

  Protein tyrosine kinases (PTKs) of Src family are important components in cellular signal transduction pathways that couple diverse extracellular signals to appropriate cellular responses . Their activities are tightly regulated in the cells and aberrant activation of some of these PTKs is associate

• Metakaolin is the product of calcination of kaolinite

  2020-07-27

  

  Metakaolin is the product of calcination of kaolinite rich clay at temperatures between 600 and 850 °C [11], [12] depending on the purity and the crystallinity of the initial clay. The geopolymers from metakaolin as aluminosilicate source have shown promising results in previous works [13], [14], [1

• Several studies suggested that Hh signaling could suppress a

  2020-07-27

  

  Several studies suggested that Hh signaling could suppress autophagy in certain types of malignant cells, while in hippocampal neurons and vascular endothelial cells, it did the opposite [7], [16], [17], [19], [30], [31]. Our results showed that GANT61 suppressed Hh signaling and boosted autophagy i

• DNA PK is a heterotrimeric

  2020-07-27

  

  DNA-PK is a heterotrimeric complex consisting of the catalytic subunit DNA-PKcs and a heterodimer of Ku70 and Ku80. DNA-PK binds dsDNA breaks and functions in non-homologous end joining (NHEJ) (Pannunzio et al., 2018) and also in DNA sensing, upregulating type I IFN and cytokines via the STING pathw

• Finally both animal models and human studies indicate that t

  2020-07-27

  

  Finally, both animal models and human studies indicate that targeting CysLT1 with the well tolerated drug montelukast, alone or combined with chemotherapeutic agents, has anti-tumor effects. Our results suggest that in lung cancer tissue, a substantial part of the LTD4 formation may proceed via tran

• We have previously characterized the leucine rich NESs locat

  2020-07-27

  

  We have previously characterized the leucine-rich NESs located within the zinc-binding domains of mucosal high risk HPV16 E7 (76IRTLEDLLM84) and low risk HPV11 E7 (76IRQLQDLLL84) mediating their nuclear export in a CRM1 dependent manner (Knapp et al., 2009, McKee et al., 2013). The zinc-binding doma

15570 records 794/1038 page Previous Next First page 上5页 791792793794795 下5页 Last page