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br Material and methods br Discussion First we investigated
2020-06-04
Material and methods Discussion First, we investigated cannabis use, and results showed that the lifetime prevalence of cannabis use in our sample was 29.63%, with a significant difference between males (73.8% of the abusers) and females (26.2%). Moreover, the mean age and age at onset were si
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CYP enzymes have an important role in
2020-06-03
CYP450 ARCA have an important role in microsomal oxidase function across a broad range of taxa (Pakharukova et al., 2012). They are involved in metabolism and detoxification of both internally generated compounds and xenobiotics as the phase I metabolizing enzymes and play an important role in main
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br Acknowledgements br Introduction Water and electrolytes c
2020-06-03
Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and progesterone receptor governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of channel proteins in ca
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br Progestogens and autoimmune diseases br
2020-06-03
Progestogens and autoimmune diseases Conclusion Take-home messages Introduction The benefits of breastfeeding for both women and their infants are considerable [1], [2], [3]. The World Health Organization (WHO) recommends infants breastfeed exclusively during the first months of life [4]
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The upregulation of PTGS and PTGS
2020-06-03
The upregulation of PTGS1 and PTGS2 in late gestation in mares could be linked to the high levels of estrogens produced by the fetoplacental unit. Estrogens are thought to be effective stimulators of prostaglandin production by potentially up regulating PTGS2 expression. Although a recent publicatio
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There are conflicting studies on
2020-06-03
There are conflicting studies on ET axis and its relationship with clinicopathologic parameters in various cancers. Endothelin axis expression in the tissue and in blood has been associated with advanced cancer characteristics in colorectal, breast, and prostate cancer, while showing no linkage to c
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dna alkylating agents The importance of EBI for B cell
2020-06-03
The importance of EBI2 for B cell function was first suggested by the dramatic upregulation of this receptor in EBV-transformed dna alkylating agents and further inferred from its regulation in activated and GC B cells (Birkenbach et al., 1993, Glynne et al., 2000, Shaffer et al., 2000). An involve
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Despite the weak and transient nature of E E
2020-06-03
Despite the weak and transient nature of E2–E3 interactions, this binding is required for the transfer of ubiquitin to the substrate. The low affinity characteristics of this interaction may be due to the fact that E2s use the same surface to interact with E1s and E3s, and hence while binding to an
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br Conclusion The role of DNA
2020-06-03
Conclusion The role of DNA-PK target in DNA DSB repair renders this Famprofazone australia kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were applied
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Protein expression and purification A mL overnight culture
2020-06-03
Protein expression and purification. A 3 mL overnight culture of E. coli BL21 (DE3) pLysS pGEX-6P-3-A1S_0222 was grown in Luria-Bertani (LB)-Medium (10 g/L tryptone, 5 g/L yeast extract, 5 g/L NaCl, pH 7.4, 100 μg/mL Amp) at 37 °C and 160 rpm. The overnight culture was diluted 1:100 into 200 mL LB (
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The hepatic cytochrome P CYP superfamily is essential
2020-06-02
The hepatic cytochrome P450 (CYP450) superfamily is essential for metabolising foreign chemicals, fatty acids, vitamins, hormones and other compounds and consists of 18 subfamilies (Uno et al., 2012). The number of discovered CYP genes is increasing as a result of intense work with CYP450 gene struc
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br Coactivator Binding Sets APC C Catalytic Core
2020-06-02
Coactivator Binding Sets APC/C Catalytic Core in Motion A coactivator not only recruits substrates to APC/C [18] (Figure 3B), but also stimulates repositioning of the catalytic core 19, 24. High-resolution cryo-EM maps of apo forms of APC/C without a coactivator show the catalytic core and platfo
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It is well established that p
2020-06-02
It is well established that p53 maintains genomic integrity in response to a variety of cell stresses including DNA damage and oncogenic stress among others [6], [7], [8], [9]. p53 promotes the expression of several genes to cause Albendazole sale arrest and to repair cellular damage. There is growi
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Despite its significance in tumor suppression the
2020-06-02
Despite its significance in tumor suppression, the molecular mechanism by which DAPK is regulated and its interplay with other tumor suppressors and oncoproteins have not been completely unraveled. Although primarily regulated by CaM binding (Cohen et al., 1997), DAPK activity can also be modulated
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The question remained as to why
2020-06-02
The question remained as to why hCrm1 was functional and mCrm1 was not in terms of Rev and HIV mRNA nuclear export, and previously we proposed three possibilities (Elinav et al., 2012). One was that human Pyridostatin had a positively acting factor that somehow stabilized the hCrm1 and Rev-RRE comp
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